The strength of the thermohaline circulation depends on the supply of warm, salty water to the North Atlantic, which, after losing heat to the atmosphere, produces the dense water masses that sink to great depths and circulate back south. Research-intensive institution faculty are: Amy Springer (U Mass Amherst), Laura Christian (West Virginia U) and Jing Zang (U of Nebraska Lincoln).Variations in the strength of the North Atlantic Ocean thermohaline circulation have been linked to rapid climate changes during the last glacial cycle through oscillations in North Atlantic Deep Water formation and northward oceanic heat flux. Community College faculty are: Tamara Mans (North Hennepin CC) and David Hecht (Southwestern CC). San Diego), John Rakus (Marshall U), Amy Parente (Mercyhurst), Kate Huisinga (Malone U), Kristin Fox (Union College), Celeste Peterson (Suffolk U), and Kevin Callahan (St. PUI faculty are: Ellis Bell, Joseph Provost, Jessica Bell and Anthony Bell (U. Another important aspect of MDH is that it is a relatively stable enzyme whose activity only requires a spectrophotometer capable of measuring absorbance at 340 nm, a resource nearly all undergraduate laboratories have availible.Ĭurrent MCC participants include: The MDH CUREs community involves a broad spectrum of 15 faculty from 12 institutions (three from research intensive institutions, two from community colleges and seven from primarily undergraduate institutions). Availability of MDH sequences for a wide array of organisms lends itself to bioinformatics approaches to develop hypotheses that can be tested experimentally. Although some forms are well characterized structurally, the relationship of such structural and functional features are not well defined across a range of evolutionarily distinct organisms. NADH) affinity), iii) Allosteric regulation (some forms are regulated by citrate inhibition and/or substrate inhibition), iv) Metabolon formation (mammalian mitochondrial MDH but not cytosolic MDH can interact with other proteins including itrate synthase) and v) Adaptation and evolution. Some examples are i) Folding and oligomeric structure (while most MDHs are dimeric, some are monomers and others form tetramers, ii) Substrate specificity (there exist MDH isoforms with LDH like activity, or NADPH (vs. There remain many unanswered fundamental questions about MDH to be investigated. Using MDH as a focus allows the MCC community to build a vibrant protein centric CURE community focusing on a recognizable and fundamental protein that can support all aspects needed to develop and expand protein based CUREs in the community. The bottom line is that the role of the instructor is minimized, there is an unknown scientific outcome and the course is designed where students are responsible for most of the work. The definitions and example syllabi for these CUREs are found in the Faculty Resource link (Model Syllabi). We are interested in the impact of collaboration between institutions and the durration of a CURE (course long or modular) on student learning gains. Others also include seven components of authentic research including: novel questions, student-generated questions, development of a hypothesis, experimental design and data collection, data analysis and presentation of research. Key elements of a CURE are reported as - the use of scientific practices, discovery, broadly relavent or important work, collaboration and iteration. A few specific publications include " Insights from a Convocation: Integrating Discovery-Based Research into the Undergraduate Curriculm", a review on CUREs for protein-based biochemistry, A practical guide to course-based undergraduate experiences, and " Assessment of course-based undergraduate research experiences: a meeting report". There are several excellent publications on the important elements of CUREs and assessment of the results of these activites.
0 kommentar(er)
